SAWC Fall 2025, September 3rd, 2025
A 67-year-old diabetic patient with polycythemia vera had a chronic heel ulcer unhealed for 9 months under standard care. ON101 induced epithelialization within 10 days, complete closure by day 14 with <1 tube and sustained healing at 6 months, demonstrating healing efficacy in complex refractory ulcers.
SAWC Fall 2025, September 3rd, 2025
Across 6 clinics in the U.S., India, and Egypt, a cohort of 42 patients with chronic DFU treated with ON101 demonstrated a 62% faster healing rate and >50% reduction in weekly clinic visits compared with historical standard of care, highlighting its efficacy in accelerating ulcer closure and reducing treatment burden.
SAWC Fall 2025, September 3rd, 2025
Among 59 patients with infected DFU (IDSA grade 2), 25 achieved complete wound closure within 8 weeks with ON101 monotherapy, accompanied by 36.7% reduced amputation rate. In complex cases involving tendon or bone exposure, combined ON101 with NPWT resulted in accelerated closure within 2–3 weeks.
SAWC Fall 2025, September 3rd, 2025
A prospective case series of 4 elderly U.S. patients with infected DFU (IDSA 2, Wagner 2), complicated by peripheral arterial disease, prolonged ulcer duration, and prior amputation (3/4), demonstrated that ON101 facilitated progressive wound size reduction and complete closure within 6–9 weeks despite underline high-risk conditions.
SAWC Spring 2025, May 1st, 2025
3 patients with Wagner Grade II DFUs had a baseline HbA1C 8.2% and mild infection. The proprietary topical cream was used when all of them were having oral antibiotics for infection control. After using the proprietary topical cream for up to 7 weeks, the wound closure occurred on all 3 patients.
EWMA 2025, Mar. 26th, 2025
ON101 topical cream is a breakthrough in DFU management, especially for high-risk, infected wounds. It delivers over 75% healing success in infected ulcers and a 0% amputation rate one year post-treatment, far outperforming standard of care. This study demonstrates superior efficacy of ON101 even at low doses, makes it a powerful and efficient solution for improving patient outcomes.
SAWC Spring 2024, May 16th, 2024
This study involved Wagner Grade 2 diabetic foot ulcer (DFU) patients with baseline HbA1c levels ranging from 6.5% to 11.8%, all unresponsive to standard care after 6 weeks. Ulcer sizes ranged from 1.39 cm² to 5.5 cm². Following clinical debridement, patients applied a proprietary natural herbal cream twice daily at home. Within 1–3 weeks, rapid improvement in the wound environment was observed, notably increased granulation tissue and accelerated healing, with some ulcers showing significant progress as early as 2–4 weeks. Remarkably, one 58-week chronic DFU healed completely in just 2 weeks after starting the treatment.
SAWC Spring 2024, May 14th, 2024
A 61-year-old man with multiple comorbidities developed wet gangrene on his right heel. Despite initial surgical interventions, poor granulation and inadequate arterial perfusion prevented flap reconstruction. Treatment with a proprietary herbal cream and absorbent dressing twice daily led to significant granulation and full calcaneal coverage in 4 weeks. A skin graft was later successful, and the patient was discharged without complications.