Effect of ON101 Topical Cream on Infected Diabetic Foot Ulcer: A Case Series in the US Elderly Patients.

Methods

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• Design: Prospective case series (n=4)
• Site: Wound Clinic at Casa Colina Hospital
• Inclusion Criteria:
  • Age > 60,  Wagner Grade 2DFU with mild infection (IDSA Grade 2)
  • Concurrent systemic antibiotics
• Exclusion Criteria: Dialysis or inadequate perfusion
• Treatment Protocol:
  • ON101 applied twice daily for up to 8 weeks
  • Weekly clinic assessment and image documentation
• Perfusion Assessment: ABI / TBI / Pedal pulse
• Outcome Measures:
  • Wound area reduction
  • Healing time
  • Safety (adverse events)

 

Executive Summary

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This case series highlights ON101’s potential as an effective adjunctive treatment for iDFUs in elderly, PAD-complicated patients. Despite advanced age (mean 72.3 yrs), amputation history (3/4), and long-standing diabetes (>10 years), ON101 facilitated:

• Fast wound closure (6-9 weeks)
• Marked wound size reduction
• No adverse effects
• High patient compliance in real-world US clinical setting
• Subjects reported decreased pain sensation

These findings suggest ON101 can enhance limb preservation and quality of life even in high-risk elderly wound populations.

 

Conclusion

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ON101 was safe, well-tolerated, and clinically effective in elderly patients with infected DFUs, promoting healing even in complex cases with amputation history and PAD.