A retrospective study comparing the efficacy of ON101 versus standard care in radiation dermatitis management

Methods

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• Study & Design: Retrospective study

• Sample Size: Total 58 patients with RTOG grade 3 or higher RD after their radiation therapy suspended.
• ON101 Group: ON101 cream was applied, a silver hydrofiber dressing was used as the secondary dressing, and the wound was covered with gauze or a hydrocolloid dressing, with dressing changes performed every three days.
• Conventional Therapy Group: Silver sulfadiazine cream or a hydrocolloid dressing was applied every three days.
• Clinical Outcomes:
  • RTOG score improvement from Day 1 to Day 9
  • VAS improvement from Day 1 to Day 9
• Statistical Analyses: Wilcoxon rank-sum tests, Fisher’s exact tests, and Chi-square tests, were conducted to compare demographic and clinical characteristics between dressing groups. Multiple regression analysis was performed to identify factors influencing treatment outcomes. All analyses were conducted using R software (version 4.4.1).

 

 

 

Results

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Conclusion

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ON101 topical cream showcased superior outcomes in treating radiation dermatitis, including improved RTOG grading that supports further radiotherapy continuation, accelerated wound recovery with reduced dressing duration, and substantial pain reduction. These promising outcomes underscore its potential as a highly effective treatment option for RD to improve patient comfort, maintaining oncologic treatment schedules, and reducing overall treatment burden.